In this article, we focus to study about well-posedness of a generalized mixed vector variational-like inequality and optimization problems with aforesaid inequality as constraint. We establish the metric characterization of well-posedness in terms of approximate solution set.Thereafter, we prove the sufficient conditions of generalized well-posedness by assuming the boundedness of approximate solution set. We also prove that the well-posedness of considered optimization problems is closely related to that of generalized mixed vector variational-like inequality problems. Moreover, we present some examples to investigate the results established in this paper.