Let X and Y be affine nonsingular real algebraic varieties. A general problem in Real Algebraic Geometry is to try to decide when a smooth map f : X -> Y can be approximated by regular maps in the space of smooth mappings from X to Y, equipped with the compact-open topology. In this paper we give a complete solution to this problem when the target space is the usual 2-dimensional sphere and the source space is a geometrically rational real algebraic surface. The approximation result for real algebraic surfaces rational over R is due to J. Bochnak and W. Kucharz. Here we give a detailed description of the more interesting case, namely a real Del Pezzo surfaces of degree 2.