Viene presentato un modello nel quale la tirosinasi occupa un ruolo centrale, come possibile regolatore della catecolaminosintesi, dell'assemblaggio dei microtubuli, della sintesi di tiroxina, della glicolisi e del ciclo dei pentosi fosfati, mediante una auto modulazione basata sul livello di tirosina e sulla produzione di melanina. Sono discusse possibili applicazioni del modello a condizioni normali e patologiche, come la fenilchetonuria, il parkinsonismo, la proliferazione dei melanociti e la rigenerazione della pelle (in condizioni fisiologiche o dopo irradiazione U.V.). Sono anche discusse brevemente le implicazioni sistemiche del modello.
@article{RLINA_1980_8_69_6_450_0,
author = {Michele Miranda and Dario Botti},
title = {Tyrosinase: a pleiotropic regulator by means of tyrosine level control and melanogenesis},
journal = {Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti},
volume = {68},
year = {1980},
pages = {450-457},
language = {en},
url = {http://dml.mathdoc.fr/item/RLINA_1980_8_69_6_450_0}
}
Miranda, Michele; Botti, Dario. Tyrosinase: a pleiotropic regulator by means of tyrosine level control and melanogenesis. Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti, Tome 68 (1980) pp. 450-457. http://gdmltest.u-ga.fr/item/RLINA_1980_8_69_6_450_0/
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