The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.
@article{bwmeta1.element.bwnjournal-article-amcv18i3p389bwm,
author = {Sandip Banerjee},
title = {Immunotherapy with interleukin-2: A study based on mathematical modeling},
journal = {International Journal of Applied Mathematics and Computer Science},
volume = {18},
year = {2008},
pages = {389-398},
zbl = {1176.93005},
language = {en},
url = {http://dml.mathdoc.fr/item/bwmeta1.element.bwnjournal-article-amcv18i3p389bwm}
}
Sandip Banerjee. Immunotherapy with interleukin-2: A study based on mathematical modeling. International Journal of Applied Mathematics and Computer Science, Tome 18 (2008) pp. 389-398. http://gdmltest.u-ga.fr/item/bwmeta1.element.bwnjournal-article-amcv18i3p389bwm/
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