Inibizione della Crescita di Cyanidium caldarium da Metionina Solfossimmina e Metionina Solfone. Due Inibitori della Glutammina Sintetasi

Rigano, Carmelo ; Di Martino Rigano, Vittoria ; Vona, Vincenza ; Aliotta, Giovanni ; Fuggi, Amodio

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti, Tome 62 (1977), p. 141-148 / Harvested from Biblioteca Digitale Italiana di Matematica

Résumé

The growth response of two strains of Cyanidium caldarium, grown in media containing ammonia or glutamate as the sole nitrogen source, to the inhibitory effect of methionine sulphoximine and methionine sulphone (which are strong specific inhibitors of glutamine synthetase) supports the claim that both strains assimilate ammonia by way of glutamine formation and that they form glutamate from glutamine. Of the two strains, one possesses glutamate dehydrogenase whereas the other lacks this enzyme activity. It seems that glutamate dehydrogenase present in one of the two strains plays only a secondary role in ammonia assimilation.

Détail

Publié le : 1977-08-01

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