A behavioural study has been conducted in mice concerning reserpine catatony and possible reversal of the same by L-Dopa or S-Adenosylmethionine alone or together. Our results show no differences in the reversal of reserpine catatony among animals treated with L-Dopa, S-Adenosylmethionine, L-Dopa + S-Adenosylmethionine or saline, the motor patterns being evaluated with a Catatony Rating Scale (CRS). Some considerations are taken into account as possible explanations. The lack of reversal of chronic reserpine catony in mice by L-Dopa shows that this model is not perfectly comparable to Parkinson's disease.
@article{RLINA_1975_8_59_5_475_0, author = {Antonio Carolei and Andrea Zamponi and Massimo Casacchia and Rosanna Cerbo and Alessandro Agnoli}, title = {Effetto sulla catatonia reserpinica di un trattamento cronico con L---Dopa ed S---Adenosilmetionina. Studio comportamentale}, journal = {Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti}, volume = {59}, year = {1975}, pages = {475-480}, language = {it}, url = {http://dml.mathdoc.fr/item/RLINA_1975_8_59_5_475_0} }
Carolei, Antonio; Zamponi, Andrea; Casacchia, Massimo; Cerbo, Rosanna; Agnoli, Alessandro. Effetto sulla catatonia reserpinica di un trattamento cronico con L—Dopa ed S—Adenosilmetionina. Studio comportamentale. Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti, Tome 59 (1975) pp. 475-480. http://gdmltest.u-ga.fr/item/RLINA_1975_8_59_5_475_0/
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