Optimal Design for Population PK/PD Models
Leonov, Sergei ; Aliev, Alexander
Tatra Mountains Mathematical Publications, Tome 51 (2012), / Harvested from Mathematical Institute
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We provide some details of the implementation of optimal design algorithm in the PkStaMplibrary which is intended for constructing optimal sampling schemes for pharmacokinetic(PK) and pharmacodynamic (PD) studies. We discuss different types of approximation ofindividual Fisher information matrix and describe a user-defined option of the library.

Publié le : 2012-01-01
DOI : https://doi.org/10.2478/tatra.v51i1.161 
@article{161,
     title = {Optimal Design for Population PK/PD Models},
     journal = {Tatra Mountains Mathematical Publications},
     volume = {51},
     year = {2012},
     doi = {10.2478/tatra.v51i1.161},
     language = {EN},
     url = {http://dml.mathdoc.fr/item/161}
}

Leonov, Sergei; Aliev, Alexander. Optimal Design for Population PK/PD Models. Tatra Mountains Mathematical Publications, Tome 51 (2012) . doi : 10.2478/tatra.v51i1.161. http://gdmltest.u-ga.fr/item/161/