Traveling waves of selective sweeps
Durrett, Rick ; Mayberry, John
Ann. Appl. Probab., Tome 21 (2011) no. 1, p. 699-744 / Harvested from Project Euclid
The goal of cancer genome sequencing projects is to determine the genetic alterations that cause common cancers. Many malignancies arise during the clonal expansion of a benign tumor which motivates the study of recurrent selective sweeps in an exponentially growing population. To better understand this process, Beerenwinkel et al. [PLoS Comput. Biol. 3 (2007) 2239–2246] consider a Wright–Fisher model in which cells from an exponentially growing population accumulate advantageous mutations. Simulations show a traveling wave in which the time of the first k-fold mutant, Tk, is approximately linear in k and heuristics are used to obtain formulas for ETk. Here, we consider the analogous problem for the Moran model and prove that as the mutation rate μ → 0, Tk ∼ ck log(1 / μ), where the ck can be computed explicitly. In addition, we derive a limiting result on a log scale for the size of Xk(t) = the number of cells with k mutations at time t.
Publié le : 2011-04-15
Classification:  Moran model,  selective sweep,  rate of adaptation,  stochastic tunneling,  branching processes,  cancer models,  60J85, 92D25,  92C50.
@article{1300800986,
     author = {Durrett, Rick and Mayberry, John},
     title = {Traveling waves of selective sweeps},
     journal = {Ann. Appl. Probab.},
     volume = {21},
     number = {1},
     year = {2011},
     pages = { 699-744},
     language = {en},
     url = {http://dml.mathdoc.fr/item/1300800986}
}
Durrett, Rick; Mayberry, John. Traveling waves of selective sweeps. Ann. Appl. Probab., Tome 21 (2011) no. 1, pp.  699-744. http://gdmltest.u-ga.fr/item/1300800986/