During the last twenty years there have been considerable methodological developments in the design and analysis of Phase 1, Phase 2 and Phase 1/2 dose-finding studies. Many of these developments are related to the continual reassessment method (CRM), first introduced by O’Quigley, Pepe and Fisher (1990). CRM models have proven themselves to be of practical use and, in this discussion, we investigate the basic approach, some connections to other methods, some generalizations, as well as further applications of the model. We obtain some new results which can provide guidance in practice.
Publié le : 2010-05-15
Classification:
Bayesian methods,
clinical trial,
continual reassessment method,
dose escalation,
dose-finding studies,
efficacy,
maximum likelihood,
maximum tolerated dose,
most successful dose,
Phase 1 trials,
Phase 2 trials,
toxicity
@article{1290175842,
author = {O'Quigley, John and Conaway, Mark},
title = {Continual Reassessment and Related Dose-Finding Designs},
journal = {Statist. Sci.},
volume = {25},
number = {1},
year = {2010},
pages = { 202-216},
language = {en},
url = {http://dml.mathdoc.fr/item/1290175842}
}
O’Quigley, John; Conaway, Mark. Continual Reassessment and Related Dose-Finding Designs. Statist. Sci., Tome 25 (2010) no. 1, pp. 202-216. http://gdmltest.u-ga.fr/item/1290175842/