The Role of Family-Based Designs in Genome-Wide Association Studies
Laird, Nan M. ; Lange, Christoph
Statist. Sci., Tome 24 (2009) no. 1, p. 388-397 / Harvested from Project Euclid
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Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.
Publié le : 2009-11-15
Classification:  Genetic association,  TDT,  FBAT,  PBAT,  two-stage designs 
@article{1271770338,
     author = {Laird, Nan M. and Lange, Christoph},
     title = {The Role of Family-Based Designs in Genome-Wide Association Studies},
     journal = {Statist. Sci.},
     volume = {24},
     number = {1},
     year = {2009},
     pages = { 388-397},
     language = {en},
     url = {http://dml.mathdoc.fr/item/1271770338}
}

Laird, Nan M.; Lange, Christoph. The Role of Family-Based Designs in Genome-Wide Association Studies. Statist. Sci., Tome 24 (2009) no. 1, pp.  388-397. http://gdmltest.u-ga.fr/item/1271770338/