A waiting time problem arising from the study of multi-stage carcinogenesis
Durrett, Rick ; Schmidt, Deena ; Schweinsberg, Jason
Ann. Appl. Probab., Tome 19 (2009) no. 1, p. 676-718 / Harvested from Project Euclid
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We consider the population genetics problem: how long does it take before some member of the population has m specified mutations? The case m=2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.
Publié le : 2009-04-15
Classification:  Multi-stage carcinogenesis,  waiting times,  Moran model,  branching process,  Wright–Fisher diffusion,  60J99,  92C50,  92D25,  60J85 
@article{1241702247,
     author = {Durrett, Rick and Schmidt, Deena and Schweinsberg, Jason},
     title = {A waiting time problem arising from the study of multi-stage carcinogenesis},
     journal = {Ann. Appl. Probab.},
     volume = {19},
     number = {1},
     year = {2009},
     pages = { 676-718},
     language = {en},
     url = {http://dml.mathdoc.fr/item/1241702247}
}

Durrett, Rick; Schmidt, Deena; Schweinsberg, Jason. A waiting time problem arising from the study of multi-stage carcinogenesis. Ann. Appl. Probab., Tome 19 (2009) no. 1, pp.  676-718. http://gdmltest.u-ga.fr/item/1241702247/