A Sequential Clinical Trial for Testing $p_1 = p_2$
Siegmund, D. ; Gregory, P.
Ann. Statist., Tome 8 (1980) no. 1, p. 1219-1228 / Harvested from Project Euclid
Text on Project Euclid
PDF
Alt PDF
Sequential designs are proposed for clinical trials to compare two binomial success probabilities, $p_1$ and $p_2$. Approximations to the operating characteristics and expected sample size are obtained and compared with simulations. Special reference is made to the problem of comparing vasopressin and placebo for stopping upper gastrointestinal hemorrhage.
Publié le : 1980-11-14
Classification:  Sequential test,  clinical trial,  stopping rule,  62L10 
@article{1176345195,
     author = {Siegmund, D. and Gregory, P.},
     title = {A Sequential Clinical Trial for Testing $p\_1 = p\_2$},
     journal = {Ann. Statist.},
     volume = {8},
     number = {1},
     year = {1980},
     pages = { 1219-1228},
     language = {en},
     url = {http://dml.mathdoc.fr/item/1176345195}
}

Siegmund, D.; Gregory, P. A Sequential Clinical Trial for Testing $p_1 = p_2$. Ann. Statist., Tome 8 (1980) no. 1, pp.  1219-1228. http://gdmltest.u-ga.fr/item/1176345195/