We discuss the concern that intensity-dependent normalization can give biased estimates of differential expression and, therefore, can misclassify some moderately important genes as unexpressed.
@article{1106314844,
author = {Ting Lee, Mei-Ling and Whitmore, George A.},
title = {Intensity-dependent normalization in microarray analysis: a note of concern},
journal = {Bernoulli},
volume = {10},
number = {2},
year = {2004},
pages = { 943-949},
language = {en},
url = {http://dml.mathdoc.fr/item/1106314844}
}
Ting Lee, Mei-Ling; Whitmore, George A. Intensity-dependent normalization in microarray analysis: a note of concern. Bernoulli, Tome 10 (2004) no. 2, pp. 943-949. http://gdmltest.u-ga.fr/item/1106314844/