It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased $\alpha$-level test and other tests which are uniformly more powerful than the
two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the $\alpha$-level two one-sided tests procedure.
Publié le : 1997-12-14
Classification:
Two one-sided tests procedure,
uniformly more powerful,
pharmocokinetic parameters,
62F04,
62P10
@article{1030741076,
author = {Brown, Lawrence D. and Hwang, J. T. Gene and Munk, Axel},
title = {An unbiased test for the bioequivalence problem},
journal = {Ann. Statist.},
volume = {25},
number = {6},
year = {1997},
pages = { 2345-2367},
language = {en},
url = {http://dml.mathdoc.fr/item/1030741076}
}
Brown, Lawrence D.; Hwang, J. T. Gene; Munk, Axel. An unbiased test for the bioequivalence problem. Ann. Statist., Tome 25 (1997) no. 6, pp. 2345-2367. http://gdmltest.u-ga.fr/item/1030741076/