We consider a class of spin systems on $\Z^d$ with vector valued spins
$(\bS_x)$ that interact via the pair-potentials $J_{x,y} \bS_x\cdot\bS_y$. The
interactions are generally spread-out in the sense that the $J_{x,y}$'s exhibit
either exponential or power-law fall-off. Under the technical condition of
reflection positivity and for sufficiently spread out interactions, we prove
that the model exhibits a first-order phase transition whenever the associated
mean-field theory signals such a transition. As a consequence, e.g., in
dimensions $d\ge3$, we can finally provide examples of the 3-state Potts model
with spread-out, exponentially decaying interactions, which undergoes a
first-order phase transition as the temperature varies. Similar transitions are
established in dimensions $d=1,2$ for power-law decaying interactions and in
high dimensions for next-nearest neighbor couplings. In addition, we also
investigate the limit of infinitely spread-out interactions. Specifically, we
show that once the mean-field theory is in a unique ``state,'' then in any
sequence of translation-invariant Gibbs states various observables converge to
their mean-field values and the states themselves converge to a product
measure.